NUAK family SNF1-like kinase 2

Definition:

Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Phosphorylates LATS1 and LATS2. Plays a key role in neural tube closure during embryonic development through LATS2 phosphorylation and regulation of the nuclear localization of YAP1 a critical downstream regulatory target in the Hippo signaling pathway.

References:

[1]. Nicolas Humbert, et al. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J. 2010 Jan 20;29(2):376-86. [Content Brief]

[2]. Jose M Lizcano, et al. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J. 2004 Feb 25;23(4):833-43. [Content Brief]

[3]. Carine Bonnard, et al. A loss-of-function NUAK2 mutation in humans causes anencephaly due to impaired Hippo-YAP signaling. J Exp Med. 2020 Dec 7;217(12):e20191561. [Content Brief]

[4]. Patrick Legembre, et al. Identification of SNF1/AMP kinase-related kinase as an NF-kappaB-regulated anti-apoptotic kinase involved in CD95-induced motility and invasiveness. J Biol Chem. 2004 Nov 5;279(45):46742-7. [Content Brief]

[5]. Atsushi Suzuki, et al. Induction of cell-cell detachment during glucose starvation through F-actin conversion by SNARK, the fourth member of the AMP-activated protein kinase catalytic subunit family. Biochem Biophys Res Commun. 2003 Nov 7;311(1):156-61. [Content Brief]

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