Nuclear body protein SP140

Definition:

Component of the nuclear body, also known as nuclear domain 10, PML oncogenic domain, and KR body. May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection. May play a role in chromatin-mediated regulation of gene expression although it does not bind to histone H3 tails.

References:

[1]. Chiara Zucchelli, et al. Structure of human Sp140 PHD finger: an atypical fold interacting with Pin1. FEBS J. 2014 Jan;281(1):216-31. [Content Brief]

[2]. D B Bloch, et al. Identification and characterization of a leukocyte-specific component of the nuclear body. J Biol Chem. 1996 Nov 15;271(46):29198-204. [Content Brief]

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