Nuclear pore complex protein Nup50

Definition:

Component of the nuclear pore complex that has a direct role in nuclear protein import. Actively displaces NLSs from importin-alpha, and facilitates disassembly of the importin-alpha:beta-cargo complex and importin recycling. Interacts with regulatory proteins of cell cycle progression including CDKN1B (By similarity). This interaction is required for correct intracellular transport and degradation of CDKN1B (By similarity).

References:

[1]. Yutaka Ogawa, et al. Two isoforms of Npap60 (Nup50) differentially regulate nuclear protein import. Mol Biol Cell. 2010 Feb 15;21(4):630-8. [Content Brief]

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