Nuclear receptor-binding factor 2

Definition:

May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro).; Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation (By similarity).

References:

[1]. Yanyan Cao, et al. NRBF2 regulates macroautophagy as a component of Vps34 Complex I. Biochem J. 2014 Jul 15;461(2):315-22. [Content Brief]

[2]. Anthony M Flores, et al. Isolation and functional analysis of a keratinocyte-derived, ligand-regulated nuclear receptor comodulator. J Invest Dermatol. 2004 Dec;123(6):1092-101. [Content Brief]

[3]. Yu Zhong, et al. Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels. J Biol Chem. 2014 Sep 19;289(38):26021-26037. [Content Brief]

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