Nuclear receptor corepressor 2

Definition:

Transcriptional corepressor. Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation.

References:

[1]. Lourdes M Mendez, et al. CtBP is an essential corepressor for BCL6 autoregulation. Mol Cell Biol. 2008 Apr;28(7):2175-86. [Content Brief]

[2]. Jiajun Cui, et al. FBI-1 functions as a novel AR co-repressor in prostate cancer cells. Cell Mol Life Sci. 2011 Mar;68(6):1091-103. [Content Brief]

[3]. Katerina Hatzi, et al. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Rep. 2013 Aug 15;4(3):578-88. [Content Brief]

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