Nuclear receptor subfamily 2 group C member 1

Definition:

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.

References:

[1]. Yun-Lu Lin, et al. Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A. Biochem Biophys Res Commun. 2006 Nov 17;350(2):430-6. [Content Brief]

[2]. Yueh-Chiang Hu, et al. Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor. J Biol Chem. 2002 Sep 13;277(37):33571-9. [Content Brief]

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