Nucleus accumbens-associated protein 2

Definition:

Functions as a transcriptional repressor through its association with the NuRD complex. Recruits the NuRD complex to the promoter of MDM2, leading to the repression of MDM2 transcription and subsequent stability of p53/TP53.

References:

[1]. C Xuan, et al. RBB, a novel transcription repressor, represses the transcription of HDM2 oncogene. Oncogene. 2013 Aug 8;32(32):3711-21. [Content Brief]

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