2. Biology Dictionary
  3. O6-methylguanine-DNA methyltransferase (MGMT)

O6-methylguanine-DNA methyltransferase (MGMT)

Definition:

O6-Methylguanine-DNA methyltransferase (MGMT) is a suicide enzyme that repairs the pre-mutagenic, pre-carcinogenic and pre-toxic DNA damage O(6)-methylguanine. It also repairs larger adducts on the O(6)-position of guanine, such as O(6)-[4-oxo-4-(3-pyridyl)butyl]guanine and O(6)-chloroethylguanine.

Biomedical Dictionary

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