Obscurin-like protein 1

Definition:

Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7-RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons.

References:

[1]. Jun Yan, et al. The 3M complex maintains microtubule and genome integrity. Mol Cell. 2014 Jun 5;54(5):791-804. [Content Brief]

[2]. Zhijun Li, et al. CUL9 mediates the functions of the 3M complex and ubiquitylates survivin to maintain genome integrity. Mol Cell. 2014 Jun 5;54(5):805-19. [Content Brief]

[3]. Nadia Litterman, et al. An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PLoS Biol. 2011 May;9(5):e1001060. [Content Brief]

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