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Olfactomedin-4

Definition:

May promote proliferation of pancreatic cancer cells by favoring the transition from the S to G2/M phase. In myeloid leukemic cell lines, inhibits cell growth and induces cell differentiation and apoptosis. May play a role in the inhibition of EIF4EBP1 phosphorylation/deactivation. Facilitates cell adhesion, most probably through interaction with cell surface lectins and cadherin.

References:

[1]. Wenli Liu, et al. The glycoprotein hGC-1 binds to cadherin and lectins. Exp Cell Res. 2006 Jun 10;312(10):1785-97. [Content Brief]

[2]. Daisuke Kobayashi, et al. Olfactomedin 4 promotes S-phase transition in proliferation of pancreatic cancer cells. Cancer Sci. 2007 Mar;98(3):334-40. [Content Brief]

[3]. Wenli Liu, et al. Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis. Blood. 2010 Dec 2;116(23):4938-47. [Content Brief]

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