Olfactory receptor 10J5
Definition:
Olfactory receptor. Activated by the synthetic floral odorant, lyral, and by alpha-cedrene, a sesquiterpene constituent of cedarwood oil. Its activation increases intracellular Ca(2+). Acts as a key regulator of myogenesis through its actions on cell migration and adhesion by activating the Ca(2+)-dependent AKT signal transduction pathway (By similarity). Acts also as a regulator of angiogenesis. Moreover, plays a role in the regulation of lipid accumulation in hepatocytes via the cAMP-PKA pathway. May be involved in sperm chemotaxis and motility (By similarity).
References:
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[1]. Tao Tong, et al. Olfactory receptor 10J5 responding to α-cedrene regulates hepatic steatosis via the cAMP-PKA pathway. Sci Rep. 2017 Aug 25;7(1):9471. [Content Brief]
[2]. Sung-Hee Kim, et al. Expression of human olfactory receptor 10J5 in heart aorta, coronary artery, and endothelial cells and its functional role in angiogenesis. Biochem Biophys Res Commun. 2015 May 1;460(2):404-8. [Content Brief]
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