Oxidoreductase HTATIP2

Definition:

Oxidoreductase required for tumor suppression. NADPH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

References:

[1]. Frank W King, et al. Inhibition of nuclear import by the proapoptotic protein CC3. Mol Cell Biol. 2004 Aug;24(16):7091-101. [Content Brief]

[2]. S Whitman, et al. Alternatively spliced products CC3 and TC3 have opposing effects on apoptosis. Mol Cell Biol. 2000 Jan;20(2):583-93. [Content Brief]

[3]. R NicAmhlaoibh, et al. Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro. Oncogene. 2001 Jan 11;20(2):270-5. [Content Brief]

[4]. E Shtivelman, et al. A link between metastasis and resistance to apoptosis of variant small cell lung carcinoma. Oncogene. 1997 May 8;14(18):2167-73. [Content Brief]

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