Oxysterol-binding protein-related protein 10

Definition:

Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.

References:

[1]. Kenji Maeda, et al. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Nature. 2013 Sep 12;501(7466):257-61. [Content Brief]

[2]. Eija Nissilä, et al. ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion. Biochim Biophys Acta. 2012 Dec;1821(12):1472-84. [Content Brief]

[3]. Monika Suchanek, et al. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Biochem J. 2007 Aug 1;405(3):473-80. [Content Brief]

[4]. Julia Perttilä, et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med (Berl). 2009 Aug;87(8):825-35. [Content Brief]

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