Oxysterol-binding protein-related protein 10

Definition

Probable lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane. Its ability to bind phosphatidylserine, suggests that it specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P (Probable). Plays a role in negative regulation of lipid biosynthesis. Negatively regulates APOB secretion from hepatocytes. Binds cholesterol and acidic phospholipids. Also binds 25-hydroxycholesterol. Binds phosphatidylserine.

References:

[1]. Kenji Maeda, et al. Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins. Nature. 2013 Sep 12;501(7466):257-61. [Content Brief]

[2]. Eija Nissilä, et al. ORP10, a cholesterol binding protein associated with microtubules, regulates apolipoprotein B-100 secretion. Biochim Biophys Acta. 2012 Dec;1821(12):1472-84. [Content Brief]

[3]. Monika Suchanek, et al. The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket. Biochem J. 2007 Aug 1;405(3):473-80. [Content Brief]

[4]. Julia Perttilä, et al. OSBPL10, a novel candidate gene for high triglyceride trait in dyslipidemic Finnish subjects, regulates cellular lipid metabolism. J Mol Med (Berl). 2009 Aug;87(8):825-35. [Content Brief]

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