RAD50-interacting protein 1

Definition:

Involved in regulation of membrane traffic between the Golgi and the endoplasmic reticulum (ER); the function is proposed to depend on its association in the NRZ complex which is believed to play a role in SNARE assembly at the ER. May play a role in cell cycle checkpoint control. Essential for telomere length control.

References:

[1]. J Xiao, et al. RINT-1, a novel Rad50-interacting protein, participates in radiation-induced G(2)/M checkpoint control. J Biol Chem. 2001 Mar 2;276(9):6105-11. [Content Brief]

[2]. Ling-Jie Kong, et al. The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1. Mol Cell. 2006 Apr 7;22(1):63-71. [Content Brief]

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