RalBP1-associated Eps domain-containing protein 2

Definition:

Involved in ligand-dependent receptor mediated endocytosis of the EGF and insulin receptors as part of the Ral signaling pathway. By controlling growth factor receptors endocytosis may regulate cell survival. Through ASAP1 may regulate cell adhesion and migration.

References:

[1]. S Nakashima, et al. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J. 1999 Jul 1;18(13):3629-42. [Content Brief]

[2]. M Ikeda, et al. Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral. J Biol Chem. 1998 Jan 9;273(2):814-21. [Content Brief]

[3]. Josien K Oosterhoff, et al. REPS2/POB1 is downregulated during human prostate cancer progression and inhibits growth factor signalling in prostate cancer cells. Oncogene. 2003 May 15;22(19):2920-5. [Content Brief]

[4]. Takafumi Oshiro, et al. Interaction of POB1, a downstream molecule of small G protein Ral, with PAG2, a paxillin-binding protein, is involved in cell migration. J Biol Chem. 2002 Oct 11;277(41):38618-26. [Content Brief]

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