Ran guanine nucleotide release factor

Definition:

May regulate the intracellular trafficking of RAN. Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1. Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics. Enhances the expression of SCN5A at the cell membrane in cardiomyocytes.

References:

[1]. K A Marfatia, et al. Identification and characterization of the human MOG1 gene. Gene. 2001 Mar 21;266(1-2):45-56. [Content Brief]

[2]. Xiaoling Bao, et al. Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation. J Mol Cell Biol. 2018 Feb 1;10(1):18-32. [Content Brief]

[3]. Ling Wu, et al. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav 1.5. J Biol Chem. 2008 Mar 14;283(11):6968-78. [Content Brief]

[4]. Susmita Chakrabarti, et al. MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome. Circ Arrhythm Electrophysiol. 2013 Apr;6(2):392-401. [Content Brief]

[5]. Morten S Olesen, et al. A novel nonsense variant in Nav1.5 cofactor MOG1 eliminates its sodium current increasing effect and may increase the risk of arrhythmias. Can J Cardiol. 2011 Jul-Aug;27(4):523.e17-23. [Content Brief]

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