Ras-related protein Rab-7b
Definition:
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.
References:
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[1]. Cinzia Progida, et al. Rab7b controls trafficking from endosomes to the TGN. J Cell Sci. 2010 May 1;123(Pt 9):1480-91. [Content Brief]
[2]. Donghua He, et al. Small Rab GTPase Rab7b promotes megakaryocytic differentiation by enhancing IL-6 production and STAT3-GATA-1 association. J Mol Med (Berl). 2011 Feb;89(2):137-50. [Content Brief]
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