Regulator of cell cycle RGCC

Definition:

Modulates the activity of cell cycle-specific kinases. Enhances CDK1 activity. May contribute to the regulation of the cell cycle. May inhibit growth of glioma cells by promoting arrest of mitotic progression at the G2/M transition. Fibrogenic factor contributing to the pathogenesis of renal fibrosis through fibroblast activation.

References:

[1]. Sandra N Schlick, et al. Upregulation of the cell-cycle regulator RGC-32 in Epstein-Barr virus-immortalized cells. PLoS One. 2011;6(12):e28638. [Content Brief]

[2]. Tudor Badea, et al. RGC-32 increases p34CDC2 kinase activity and entry of aortic smooth muscle cells into S-phase. J Biol Chem. 2002 Jan 4;277(1):502-8. [Content Brief]

[3]. K Saigusa, et al. RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest. Oncogene. 2007 Feb 22;26(8):1110-21. [Content Brief]

[4]. Wen-Yan Huang, et al. RGC-32 mediates transforming growth factor-beta-induced epithelial-mesenchymal transition in human renal proximal tubular cells. J Biol Chem. 2009 Apr 3;284(14):9426-32. [Content Brief]

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