Rho family-interacting cell polarization regulator 1

Definition:

Downstream effector protein for Rho-type small GTPases that plays a role in cell polarity and directional migration. Acts as an adapter protein, linking active Rho proteins to STK24 and STK26 kinases, and hence positively regulates Golgi reorientation in polarized cell migration upon Rho activation. Involved in the subcellular relocation of STK26 from the Golgi to cytoplasm punctae in a Rho- and PDCD10-dependent manner upon serum stimulation.

References:

[1]. Faraz K Mardakheh, et al. RHO binding to FAM65A regulates Golgi reorientation during cell migration. J Cell Sci. 2016 Dec 15;129(24):4466-4479. [Content Brief]

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