Rho guanine nucleotide exchange factor 25

Definition:

May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).

References:

[1]. Xiangrong Guo, et al. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. J Biol Chem. 2003 Apr 11;278(15):13207-15. [Content Brief]

[2]. Michel Souchet, et al. Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere. J Cell Sci. 2002 Feb 1;115(Pt 3):629-40. [Content Brief]

[3]. Susanne Lutz, et al. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. Naunyn Schmiedebergs Arch Pharmacol. 2004 May;369(5):540-6. [Content Brief]

[4]. Susanne Lutz, et al. The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. J Biol Chem. 2005 Mar 25;280(12):11134-9. [Content Brief]

[5]. Brad A Bryan, et al. Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. Mol Cell Biol. 2005 Dec;25(24):11089-101. [Content Brief]

[6]. Rafael J Rojas, et al. Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain. J Biol Chem. 2007 Oct 5;282(40):29201-10. [Content Brief]

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