Rho guanine nucleotide exchange factor 4
Definition:
References:
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[1]. Y Kawasaki, et al. Asef, a link between the tumor suppressor APC and G-protein signaling. Science. 2000 Aug 18;289(5482):1194-7. [Content Brief]
[2]. Yoshihiro Kawasaki, et al. Mutated APC and Asef are involved in the migration of colorectal tumour cells. Nat Cell Biol. 2003 Mar;5(3):211-5. [Content Brief]
[3]. Y Kawasaki, et al. Identification and characterization of Asef2, a guanine-nucleotide exchange factor specific for Rac1 and Cdc42. Oncogene. 2007 Dec 6;26(55):7620-267. [Content Brief]
[4]. Yoshihiro Kawasaki, et al. The adenomatous polyposis coli-associated exchange factors Asef and Asef2 are required for adenoma formation in Apc(Min/+)mice. EMBO Rep. 2009 Dec;10(12):1355-62. [Content Brief]
[5]. Michael J Hamann, et al. Asef2 functions as a Cdc42 exchange factor and is stimulated by the release of an autoinhibitory module from a concealed C-terminal activation element. Mol Cell Biol. 2007 Feb;27(4):1380-93. [Content Brief]
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