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Seipin

Definition:

Plays a crucial role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis. In association with LDAF1, defines the sites of LD formation in the ER. Also required for growth and maturation of small nascent LDs into larger mature LDs. Mediates the formation and/or stabilization of endoplasmic reticulum-lipid droplets (ER-LD) contacts, facilitating protein and lipid delivery from the ER into growing LDs. Regulates the maturation of ZFYVE1-positive nascent LDs and the function of the RAB18-ZFYVE1 complex in mediating the formation of ER-LD contacts. Binds anionic phospholipids including phosphatidic acid. Plays an important role in the differentiation and development of adipocytes (By similarity).

References:

[1]. Renhong Yan, et al. Human SEIPIN Binds Anionic Phospholipids. Dev Cell. 2018 Oct 22;47(2):248-256.e4. [Content Brief]

[2]. Jeeyun Chung, et al. LDAF1 and Seipin Form a Lipid Droplet Assembly Complex. Dev Cell. 2019 Dec 2;51(5):551-563.e7. [Content Brief]

[3]. Huajin Wang, et al. Seipin is required for converting nascent to mature lipid droplets. Elife. 2016 Aug 26;5:e16582. [Content Brief]

[4]. Veijo T Salo, et al. Seipin regulates ER-lipid droplet contacts and cargo delivery. EMBO J. 2016 Dec 15;35(24):2699-2716. [Content Brief]

[5]. Dongfang Li, et al. The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation. Cell Rep. 2019 Apr 9;27(2):343-358.e5. [Content Brief]

[6]. Yuan Tian, et al. Tissue-autonomous function of Drosophila seipin in preventing ectopic lipid droplet formation. PLoS Genet. 2011 Apr;7(4):e1001364. [Content Brief]

[7]. Veijo T Salo, et al. Seipin Facilitates Triglyceride Flow to Lipid Droplet and Counteracts Droplet Ripening via Endoplasmic Reticulum Contact. Dev Cell. 2019 Aug 19;50(4):478-493.e9. [Content Brief]

[8]. Emilie Boutet, et al. Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy. Biochimie. 2009 Jun;91(6):796-803. [Content Brief]

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