Serine/Arginine-related protein 53

Definition:

Has a role in alternative splicing and transcription regulation. Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing.

References:

[1]. Demian Cazalla, et al. A novel SR-related protein is required for the second step of Pre-mRNA splicing. Mol Cell Biol. 2005 Apr;25(8):2969-80. [Content Brief]

[2]. Yonatan Perez, et al. RSRC1 mutation affects intellect and behaviour through aberrant splicing and transcription, downregulating IGFBP3. Brain. 2018 Apr 1;141(4):961-970. [Content Brief]

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