Serine/arginine-rich splicing factor 6

Definition:

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing.

References:

[1]. Quincy Tran, et al. SRp55 is a regulator of calcitonin/CGRP alternative RNA splicing. Biochemistry. 2003 Feb 4;42(4):951-7. [Content Brief]

[2]. Mads A Jensen, et al. Splicing factor SRSF6 promotes hyperplasia of sensitized skin. Nat Struct Mol Biol. 2014 Feb;21(2):189-97. [Content Brief]

[3]. Junning Wang, et al. Tau exon 10, whose missplicing causes frontotemporal dementia, is regulated by an intricate interplay of cis elements and trans factors. J Neurochem. 2004 Mar;88(5):1078-90. [Content Brief]

[4]. Xiaomin Yin, et al. Dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A) modulates serine/arginine-rich protein 55 (SRp55)-promoted Tau exon 10 inclusion. J Biol Chem. 2012 Aug 31;287(36):30497-506. [Content Brief]

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