Serine protease 57

Definition:

Serine protease that cleaves preferentially after Arg residues. Can also cleave after citrulline (deimidated arginine) and methylarginine residues.

References:

[1]. Natascha C Perera, et al. NSP4, an elastase-related protease in human neutrophils with arginine specificity. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6229-34. [Content Brief]

[2]. S Jack Lin, et al. Structures of neutrophil serine protease 4 reveal an unusual mechanism of substrate recognition by a trypsin-fold protease. Structure. 2014 Sep 2;22(9):1333-1340. [Content Brief]

[3]. Natascha C Perera, et al. NSP4 is stored in azurophil granules and released by activated neutrophils as active endoprotease with restricted specificity. J Immunol. 2013 Sep 1;191(5):2700-7. [Content Brief]

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