Serine/threonine-protein phosphatase CPPED1

Definition:

Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes.

References:

[1]. Maija Vaittinen, et al. Downregulation of CPPED1 expression improves glucose metabolism in vitro in adipocytes. Diabetes. 2013 Nov;62(11):3747-50. [Content Brief]

[2]. De-Xiang Zhuo, et al. CSTP1, a novel protein phosphatase, blocks cell cycle, promotes cell apoptosis, and suppresses tumor growth of bladder cancer by directly dephosphorylating Akt at Ser473 site. PLoS One. 2013 Jun 17;8(6):e65679. [Content Brief]

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