Serpin B10

Definition:

Protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. May regulate protease activities in the cytoplasm and in the nucleus.

References:

[1]. M Riewald, et al. Molecular cloning of bomapin (protease inhibitor 10), a novel human serpin that is expressed specifically in the bone marrow. J Biol Chem. 1995 Nov 10;270(45):26754-7. [Content Brief]

[2]. R R Schleef, et al. Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced cell death. Evidence for the formation of intracellular high M(r) protease inhibitor 10-containing complexes. J Biol Chem. 2000 Aug 25;275(34):26385-9. [Content Brief]

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