Sialidase-4

Definition:

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (By similarity). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose.

References:

[1]. Kazunori Yamaguchi, et al. Evidence for mitochondrial localization of a novel human sialidase (NEU4). Biochem J. 2005 Aug 15;390(Pt 1):85-93. [Content Brief]

[2]. Kazuhiro Shiozaki, et al. Regulation of sialyl Lewis antigen expression in colon cancer cells by sialidase NEU4. J Biol Chem. 2011 Jun 17;286(24):21052-61. [Content Brief]

[3]. Volkan Seyrantepe, et al. Neu4, a novel human lysosomal lumen sialidase, confers normal phenotype to sialidosis and galactosialidosis cells. J Biol Chem. 2004 Aug 27;279(35):37021-9. [Content Brief]

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