Sigma intracellular receptor 2

Definition:

Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cancer cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. Under investigation for its potential diagnostic and therapeutic uses. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.

References:

[1]. Lin Guo, et al. Sigma-2 receptor ligands: neurobiological effects. Curr Med Chem. 2015;22(8):989-1003. [Content Brief]

[2]. Fabian Bartz, et al. Identification of cholesterol-regulating genes by targeted RNAi screening. Cell Metab. 2009 Jul;10(1):63-75. [Content Brief]

[3]. Assaf Alon, et al. Identification of the gene that codes for the σ2 receptor. Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):7160-7165. [Content Brief]

[4]. Yun-Sheng Huang, et al. Sigma-2 receptor ligands and their perspectives in cancer diagnosis and therapy. Med Res Rev. 2014 May;34(3):532-66. [Content Brief]

[5]. Luis Sanchez-Pulido, et al. TM6SF2 and MAC30, new enzyme homologs in sterol metabolism and common metabolic disease. Front Genet. 2014 Dec 11;5:439. [Content Brief]

[6]. Ikhlas S A Ahmed, et al. S2R(Pgrmc1): the cytochrome-related sigma-2 receptor that regulates lipid and drug metabolism and hormone signaling. Expert Opin Drug Metab Toxicol. 2012 Mar;8(3):361-70. [Content Brief]

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