Sister chromatid cohesion protein DCC1

Definition:

Loads PCNA onto primed templates regulating velocity, spacing and restart activity of replication forks. May couple DNA replication to sister chromatid cohesion through regulation of the acetylation of the cohesin subunit SMC3.

References:

[1]. Marie-Emilie Terret, et al. Cohesin acetylation speeds the replication fork. Nature. 2009 Nov 12;462(7270):231-4. [Content Brief]

[2]. Carolin J Merkle, et al. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. J Biol Chem. 2003 Aug 8;278(32):30051-6. [Content Brief]

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