SLIT-ROBO Rho GTPase-activating protein 3

Definition:

GTPase-activating protein for RAC1 and perhaps Cdc42, but not for RhoA small GTPase. May attenuate RAC1 signaling in neurons.

References:

[1]. Scott H Soderling, et al. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat Cell Biol. 2002 Dec;4(12):970-5. [Content Brief]

[2]. Volker Endris, et al. The novel Rho-GTPase activating gene MEGAP/ srGAP3 has a putative role in severe mental retardation. Proc Natl Acad Sci U S A. 2002 Sep 3;99(18):11754-9. [Content Brief]

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