Sodium- and chloride-dependent glycine transporter 2

Definition:

Sodium- and chloride-dependent glycine transporter. Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May be responsible for the termination of neurotransmission at strychnine-sensitive glycinergic synapses.; [Isoform 2]: Lacks sodium- and chloride-dependent glycine transporter activity.; [Isoform 3]: Lacks sodium- and chloride-dependent glycine transporter activity.

References:

[1]. M J Gallagher, et al. Characterization of multiple forms of the human glycine transporter type-2. Brain Res Mol Brain Res. 1999 Jun 18;70(1):101-15. [Content Brief]

[2]. Mark I Rees, et al. Mutations in the gene encoding GlyT2 (SLC6A5) define a presynaptic component of human startle disease. Nat Genet. 2006 Jul;38(7):801-6. [Content Brief]

[3]. J Evans, et al. Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter. FEBS Lett. 1999 Dec 17;463(3):301-6. [Content Brief]

[4]. Alexandra Kitzenmaier, et al. The P429L loss of function mutation of the human glycine transporter 2 associated with hyperekplexia. Eur J Neurosci. 2019 Dec;50(12):3906-3920. [Content Brief]

[5]. J A Morrow, et al. Molecular cloning and functional expression of the human glycine transporter GlyT2 and chromosomal localisation of the gene in the human genome. FEBS Lett. 1998 Nov 20;439(3):334-40. [Content Brief]

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