Sodium- and chloride-dependent transporter XTRP3

Definition:

Mediates the Na(+)- and Cl(-)-dependent uptake of imino acids such as L-proline, N-methyl-L-proline and pipecolate as well as N-methylated amino acids. Also transports glycine, regulates proline and glycine homeostasis in the brain playing a role in the modulation of NMDAR currents.

References:

[1]. Mihyun Bae, et al. SLC6A20 transporter: a novel regulator of brain glycine homeostasis and NMDAR function. EMBO Mol Med. 2021 Feb 5;13(2):e12632. [Content Brief]

[2]. Hitomi Takanaga, et al. Identification of mammalian proline transporter SIT1 (SLC6A20) with characteristics of classical system imino. J Biol Chem. 2005 Mar 11;280(10):8974-84. [Content Brief]

[3]. Stefan Bröer, et al. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. J Clin Invest. 2008 Dec;118(12):3881-92. [Content Brief]

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