Sodium-dependent noradrenaline transporter

Definition:

Mediates sodium- and chloride-dependent transport of norepinephrine (also known as noradrenaline). Can also mediate sodium- and chloride-dependent transport of dopamine.

References:

[1]. T Pacholczyk, et al. Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. 1991 Mar 28;350(6316):350-4. [Content Brief]

[2]. H Gu, et al. Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. J Biol Chem. 1994 Mar 11;269(10):7124-30. [Content Brief]

[3]. M Syringas, et al. Structural domains of chimeric dopamine-noradrenaline human transporters involved in the Na(+)- and Cl(-)-dependence of dopamine transport. Mol Pharmacol. 2000 Dec;58(6):1404-11. [Content Brief]

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