Solute carrier family 12 member 4

Definition:

Mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May contribute to cell volume homeostasis in single cells. May be involved in the regulation of basolateral Cl(-) exit in NaCl absorbing epithelia (By similarity).; [Isoform 4]: No transporter activity.

References:

[1]. A Mercado, et al. Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4. J Biol Chem. 2000 Sep 29;275(39):30326-34. [Content Brief]

[2]. Gamma Chi, et al. Phospho-regulation, nucleotide binding and ion access control in potassium-chloride cotransporters. EMBO J. 2021 Jul 15;40(14):e107294. [Content Brief]

[3]. S Casula, et al. A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity. J Biol Chem. 2001 Nov 9;276(45):41870-8. [Content Brief]

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