Solute carrier family 5 member 4

Definition:

Has electrogenic activity in response to glucose, and may function as a glucose sensor. Mediates influx of sodium ions into the cell but does not transport sugars. Also potently activated by imino sugars such as deoxynojirimycin (DNJ).

References:

[1]. Rajendra K Kothinti, et al. A novel SGLT is expressed in the human kidney. Eur J Pharmacol. 2012 Sep 5;690(1-3):77-83. [Content Brief]

[2]. Andrew A Voss, et al. Imino sugars are potent agonists of the human glucose sensor SGLT3. Mol Pharmacol. 2007 Feb;71(2):628-34. [Content Brief]

[3]. Ana Diez-Sampedro, et al. A glucose sensor hiding in a family of transporters. Proc Natl Acad Sci U S A. 2003 Sep 30;100(20):11753-8. [Content Brief]

[4]. Laura Bianchi, et al. A single amino acid change converts the sugar sensor SGLT3 into a sugar transporter. PLoS One. 2010 Apr 20;5(4):e10241. [Content Brief]

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