Sorting and assembly machinery component 50 homolog

Definition:

Plays a crucial role in the maintenance of the structure of mitochondrial cristae and the proper assembly of the mitochondrial respiratory chain complexes. Required for the assembly of TOMM40 into the TOM complex.

References:

[1]. Adam D Humphries, et al. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005 Mar 25;280(12):11535-43. [Content Brief]

[2]. Christine Ott, et al. Detailed analysis of the human mitochondrial contact site complex indicate a hierarchy of subunits. PLoS One. 2015 Mar 17;10(3):e0120213. [Content Brief]

[3]. Christine Ott, et al. Sam50 functions in mitochondrial intermembrane space bridging and biogenesis of respiratory complexes. Mol Cell Biol. 2012 Mar;32(6):1173-88. [Content Brief]

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