Sperm-associated antigen 5

Definition:

Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. In complex with SKAP, promotes stable microtubule-kinetochore attachments. May contribute to the regulation of separase activity. May regulate AURKA localization to mitotic spindle, but not to centrosomes and CCNB1 localization to both mitotic spindle and centrosomes. Involved in centriole duplication. Required for CDK5RAP2, CEP152, WDR62 and CEP63 centrosomal localization and promotes the centrosomal localization of CDK2. In non-mitotic cells, upon stress induction, inhibits mammalian target of rapamycin complex 1 (mTORC1) association and recruits the mTORC1 component RPTOR to stress granules (SGs), thereby preventing mTORC1 hyperactivation-induced apoptosis. May enhance GSK3B-mediated phosphorylation of other substrates, such as MAPT/TAU.

References:

[1]. Jian Du, et al. Astrin regulates Aurora-A localization. Biochem Biophys Res Commun. 2008 May 30;370(2):213-9. [Content Brief]

[2]. Kathrin Thedieck, et al. Inhibition of mTORC1 by astrin and stress granules prevents apoptosis in cancer cells. Cell. 2013 Aug 15;154(4):859-74. [Content Brief]

[3]. Jens Gruber, et al. The mitotic-spindle-associated protein astrin is essential for progression through mitosis. J Cell Sci. 2002 Nov 1;115(Pt 21):4053-9. [Content Brief]

[4]. Xiaogang Chu, et al. Nuclear Mitotic Apparatus (NuMA) Interacts with and Regulates Astrin at the Mitotic Spindle. J Biol Chem. 2016 Sep 16;291(38):20055-67. [Content Brief]

[5]. Kerstin H Thein, et al. Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity. J Cell Biol. 2007 Jul 30;178(3):345-54. [Content Brief]

[6]. Andrew Kodani, et al. Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication. Elife. 2015 Aug 22;4:e07519. [Content Brief]

[7]. Tai-Shan Cheng, et al. Glycogen synthase kinase 3beta interacts with and phosphorylates the spindle-associated protein astrin. J Biol Chem. 2008 Jan 25;283(4):2454-64. [Content Brief]

[8]. Anja K Dunsch, et al. The astrin-kinastrin/SKAP complex localizes to microtubule plus ends and facilitates chromosome alignment. J Cell Biol. 2011 Mar 21;192(6):959-68. [Content Brief]

[9]. G J Mack, et al. Analysis of mitotic microtubule-associated proteins using mass spectrometry identifies astrin, a spindle-associated protein. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14434-9. [Content Brief]

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