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Spindle assembly abnormal protein 6 homolog

Definition:

Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells. Overexpression results in excess foci-bearing centriolar markers. Required for the recruitment of STIL to the procentriole and for STIL-mediated centriole amplification.

References:

[1]. Julia Kleylein-Sohn, et al. Plk4-induced centriole biogenesis in human cells. Dev Cell. 2007 Aug;13(2):190-202. [Content Brief]

[2]. Robert Habedanck, et al. The Polo kinase Plk4 functions in centriole duplication. Nat Cell Biol. 2005 Nov;7(11):1140-6. [Content Brief]

[3]. Chieh-Ju C Tang, et al. The human microcephaly protein STIL interacts with CPAP and is required for procentriole formation. EMBO J. 2011 Oct 21;30(23):4790-804. [Content Brief]

[4]. Sebastian Leidel, et al. SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells. Nat Cell Biol. 2005 Feb;7(2):115-25. [Content Brief]

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