Striate palmoplantar keratoderma

Definition:

Striate palmoplantar keratoderma (SPPK) is an autosomal dominant genodermatosis characterized by linear hyperkeratosis of volar aspects of the fingers and on the palm as well as by focal hyperkeratosis on the soles. SPPK is a heterogenous group of disorders caused by mutations in either desmoglein 1 (DSG1), desmoplakin (DSP), or keratin 1 (KRT1).

References:

[1]. Alison G Barber, et al. Striate palmoplantar keratoderma resulting from a frameshift mutation in the desmoglein 1 gene. J Dermatol Sci. 2007 Mar;45(3):161-6. [Content Brief]

[2]. Kazuhiro Kawai, et al. Striate palmoplantar keratoderma. J Dermatol. 2010 Sep;37(9):854-6. [Content Brief]

[3]. M Zamiri, et al. Mutation in DSG1 causing autosomal dominant striate palmoplantar keratoderma. Br J Dermatol. 2009 Sep;161(3):692-4. [Content Brief]

[4]. Neil V Whittock, et al. Frameshift mutation in the V2 domain of human keratin 1 results in striate palmoplantar keratoderma. J Invest Dermatol. 2002 May;118(5):838-44. [Content Brief]

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