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Sulfotransferase 1C2

Definition:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation. Sulfonates p-nitrophenol, a small phenolic compond. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol. Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis.

References:

[1]. R R Freimuth, et al. Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization. Genomics. 2000 Apr 15;65(2):157-65. [Content Brief]

[2]. N Hehonah, et al. Molecular cloning, expression, localisation and functional characterisation of a rabbit SULT1C2 sulfotransferase. Int J Biochem Cell Biol. 1999 Aug;31(8):869-82. [Content Brief]

[3]. Y Sakakibara, et al. Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene. J Biol Chem. 1998 Dec 18;273(51):33929-35. [Content Brief]

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