Ubiquitin carboxyl-terminal hydrolase 24

Definition:

Ubiquitin-specific protease that regulates cell survival in various contexts through modulating the protein stability of some of its substrates including DDB2, MCL1 or TP53. Plays a positive role on ferritinophagy where ferritin is degraded in lysosomes and releases free iron.

References:

[1]. Ling Zhang, et al. The deubiquitinating protein USP24 interacts with DDB2 and regulates DDB2 stability. Cell Cycle. 2012 Dec 1;11(23):4378-84. [Content Brief]

[2]. Yamei Sun, et al. Human Cytomegalovirus Protein pUL38 Prevents Premature Cell Death by Binding to Ubiquitin-Specific Protease 24 and Regulating Iron Metabolism. J Virol. 2018 Jun 13;92(13):e00191-18. [Content Brief]

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