Ubiquitin carboxyl-terminal hydrolase 47

Definition:

Ubiquitin-specific protease that specifically deubiquitinates monoubiquitinated DNA polymerase beta (POLB), stabilizing POLB thereby playing a role in base-excision repair (BER). Acts as a regulator of cell growth and genome integrity. May also indirectly regulate CDC25A expression at a transcriptional level.

References:

[1]. A Peschiaroli, et al. The ubiquitin-specific protease USP47 is a novel beta-TRCP interactor regulating cell survival. Oncogene. 2010 Mar 4;29(9):1384-93. [Content Brief]

[2]. Jason L Parsons, et al. USP47 is a deubiquitylating enzyme that regulates base excision repair by controlling steady-state levels of DNA polymerase β. Mol Cell. 2011 Mar 4;41(5):609-15. [Content Brief]

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