Ubiquitin-conjugating enzyme E2 H

Definition:

Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. E2 ubiquitin conjugating enzyme that transfers ubiquitin to MAEA, a core component of the CTLH E3 ubiquitin-protein ligase complex. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A.

References:

[1]. P Kaiser, et al. A human ubiquitin-conjugating enzyme homologous to yeast UBC8. J Biol Chem. 1994 Mar 25;269(12):8797-802. [Content Brief]

[2]. Daniela Hoeller, et al. E3-independent monoubiquitination of ubiquitin-binding proteins. Mol Cell. 2007 Jun 22;26(6):891-8. [Content Brief]

[3]. Yael David, et al. The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J Biol Chem. 2010 Mar 19;285(12):8595-604. [Content Brief]

[4]. Fabienne Lampert, et al. The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation. Elife. 2018 Jun 18;7:e35528. [Content Brief]

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