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Unconventional myosin-Vb

Definition:

May be involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Required in a complex with RAB11A and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Together with RAB11A participates in CFTR trafficking to the plasma membrane and TF (transferrin) recycling in nonpolarized cells. Together with RAB11A and RAB8A participates in epithelial cell polarization. Together with RAB25 regulates transcytosis. Required for proper localization of bile salt export pump ABCB11 at the apical/canalicular plasma membrane of hepatocytes.

References:

[1]. Jiaqi Lu, et al. Two cases of microvillus inclusion disease caused by MYO5B deficiency with prenatal abnormalities. Prenat Diagn. 2022 Jan;42(1):136-140. [Content Brief]

[2]. Joseph T Roland, et al. Rab GTPase-Myo5B complexes control membrane recycling and epithelial polarization. Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2789-94. [Content Brief]

[3]. Agata M Szperl, et al. Functional characterization of mutations in the myosin Vb gene associated with microvillus inclusion disease. J Pediatr Gastroenterol Nutr. 2011 Mar;52(3):307-13. [Content Brief]

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