Unfolded protein-response (UPR)

Definition:

Unfolded protein-response (UPR) is a cellular stress response aboutthe endoplasmic reticulum (ER) stress. Unfolded protein response (UPR), acts as homeostatic signalling network that orchestrates the recovery of ER function, and failure to adapt to ER stress results in apoptosis.

References:

[1]. Hetz C. The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol. 2012 Jan 18;13(2):89-102. [Content Brief]

[2]. Hetz C, et al. The Unfolded Protein Response and Cell Fate Control. Mol Cell. 2018 Jan 18;69(2):169-181. [Content Brief]

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