V-set and immunoglobulin domain-containing protein 4

Definition:

Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases.

References:

[1]. Lorenz Vogt, et al. VSIG4, a B7 family-related protein, is a negative regulator of T cell activation. J Clin Invest. 2006 Oct;116(10):2817-26. [Content Brief]

[2]. Christian Wiesmann, et al. Structure of C3b in complex with CRIg gives insights into regulation of complement activation. Nature. 2006 Nov 9;444(7116):217-20. [Content Brief]

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