Vaccinia

Definition:

Vaccinia is an infectious disease caused by vaccinia virus, an orthopoxvirus in the Poxviridae family of dsDNA viruses. Vaccinia virus has been used as a smallpox vaccine. Several serious complications such as encephalitis, progressive vaccinia, eczema vaccinatum, and generalized vaccinia and disseminated vaccinia have been reported.

References:

[1]. Jaqueline Silva de Oliveira, et al. Vaccinia Virus Natural Infections in Brazil: The Good, the Bad, and the Ugly. Viruses. 2017 Nov 15;9(11):340. [Content Brief]

[2]. Mike Bray, et al. Pathogenesis and potential antiviral therapy of complications of smallpox vaccination. Antiviral Res. 2003 Apr;58(2):101-14. [Content Brief]

[3]. Sandra Essbauer, et al. Zoonotic poxviruses. Vet Microbiol. 2010 Jan 27;140(3-4):229-36. [Content Brief]

[4]. Stephen R Walsh, et al. Vaccinia viruses: vaccines against smallpox and vectors against infectious diseases and tumors. Expert Rev Vaccines. 2011 Aug;10(8):1221-40. [Content Brief]

[5]. Tomás J Aragón, et al. Risks of serious complications and death from smallpox vaccination: a systematic review of the United States experience, 1963-1968. BMC Public Health. 2003 Aug 11;3:26. [Content Brief]

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