Vacuolar protein sorting-associated protein 54

Definition:

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling.

References:

[1]. Christina Schindler, et al. EARP is a multisubunit tethering complex involved in endocytic recycling. Nat Cell Biol. 2015 May;17(5):639-50. [Content Brief]

[2]. F Javier Pérez-Victoria, et al. Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes. Mol Biol Cell. 2008 Jun;19(6):2350-62. [Content Brief]

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