Vacuolar protein sorting-associated protein 8 homolog

Definition:

Plays a role in vesicle-mediated protein trafficking of the endocytic membrane transport pathway. Believed to act as a component of the putative CORVET endosomal tethering complexes which is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations. Functions predominantly in APPL1-containing endosomes.

References:

[1]. Enrico D Perini, et al. Mammalian CORVET is required for fusion and conversion of distinct early endosome subpopulations. Traffic. 2014 Dec;15(12):1366-89. [Content Brief]

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